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Featured Publications

Hardcover Books
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October 5, 2022

Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration

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August 4, 2022

Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

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February 14, 2022

Single-cell dissection of the human brain vasculature

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December 16, 2021

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

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November 8, 2021

Dissecting the complexities of Alzheimer disease with in vitro models of the human brain

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September 6, 2021

Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration

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June 21, 2021

Identification of sixteen novel candidate genes for late onset Parkinson's disease

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October 20, 2020

Applying available knowledge and resources to alleviate familial and sporadic neurodegenerative disorders

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June, 2020

TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS

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May, 2020

Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

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December 26, 2019

Effects of Intermittent Fasting on Health, Aging, and Disease

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August 7, 2019

Modeling Alzheimer's disease with iPSC-derived brain cells

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May 1, 2019

Single-cell transcriptomic analysis of Alzheimer’s disease

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April 4, 2019

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition

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September 5, 2018

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

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January, 2018

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

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April 5, 2017

Mutant Huntingtin Disrupts the Nuclear Pore Complex

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September 1, 2016

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

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August 26, 2015

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

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March, 2014

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

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September, 2011

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease

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September 30, 2022

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

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June 24, 2022

Mitochondrial SIRT3 Deficiency Results in Neuronal Network Hyperexcitability, Accelerates Age-Related Aβ Pathology, and Renders Neurons Vulnerable to Aβ Toxicity

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February 3, 2022

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

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December 8, 2021

Superhuman cell death detection with biomarker-optimized neural networks

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November 3, 2021

MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

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August 17, 2021

Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function

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June 1, 2021

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

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September 23, 2020

Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease

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May 18, 2020

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

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January 15, 2020

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model

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September 4, 2019

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

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June 5, 2019

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

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April 23, 2019

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

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April 01, 2019

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

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May 3, 2018

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

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October, 2017

KPT-350 reduces neurodegeneration and rescues aberrant nucleocytoplasmic transport in drosophila model of C9ORF72 ALS/FTD

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March, 2017

Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

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May 19, 2016

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

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July, 2015

Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase

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November, 2014

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

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September 28, 2022

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

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June 7, 2022

Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

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February, 2022

Harnessing cerebral organoids for Alzheimer's disease research

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December, 2021

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models

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October 12, 2021

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

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July, 2021

Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation

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March 3, 2021

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

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June 8, 2020

Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

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May 7, 2020

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease

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January 8, 2020

Approaches to develop therapeutics to treat frontotemporal dementia

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September, 2019

Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice

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May 13, 2019

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models

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April 12, 2019

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

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March 11, 2019

The complexity of neuroinflammation at single-cell resolution

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April 19, 2018

In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images

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April 24, 2017

Brain metabolism in health, aging, and neurodegeneration

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January 31, 2017

Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis

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April 25, 2016

Nucleocytoplasmic transport in C9orf72-mediated ALS/FTD

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December, 2014

Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?

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December, 2011

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3

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Image by Josh Appel

Neurodegenerative Diseases

Understanding complex and devastating neurodegenerative diseases

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Traffic Jams in  Neurodegeneration

How exciting is the linkage between both the NPC and NCT with neurodegeneration?

Pipetting Samples

Informed Pipeline

Making data informed decisions to build a robust pipeline

DNA

TM

PurPrecision    Drug Discovery Platform

Building a platform that uses lessons from our novel discovery for the future